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KMID : 1149220090170020175
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Korean Journal of Oriental Medical Prescription
2009 Volume.17 No. 2 p.175 ~ p.186
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Effect of Lophatherum gracile on the mechanism of vasorelaxation in thoracic aorta
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Kim Hye-Yoom
Li Xiang
Lee Yun-Jung
Seo Hwan-Ho
Cho Nam-Geun
Kang Dae-Gil
Lee Ho-Sub
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Abstract
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The vasorelaxant effect of an extract of Lophatherum gracile Brongn (ELB) and its possible action mechanism were ascertained in aortic tissues isolated from rats. ELB relaxed endothelium-intact thoracic aorta in a dose-dependent manner. However, the induced vascular relaxation was abolished by removal in endothelium of the thoracic aorta. Pretreatment of endothelium-intact vascular tissues with NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-1-one (ODQ) significantly inhibited vascular relaxation induced by ELB. Moreover, ELB significantly increased cGMP production in aortic tissues, which was blocked by pretreatment with L-NAME or ODQ. The vasorelaxant effect of ELB was attenuated by tetraethylammonium (TEA), and glibenclamide. ELB-induced vasorelaxation was not blocked by atropine, propranolol, indomethacin, verapamil, and diltiazem. Taken together, the present study demonstrates that ELB dilates vascular smooth muscle via an endothelium-dependent NO-cGMP signaling pathway, which may be at least in part related with the function of K+ channels.
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KEYWORD
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ethanol extract of Lophatherum gracile Brongn (ELB), aortic tissues, endothelium, nitric oxide/cGMP, vascular relaxation
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